Table 3.
Secondary Endpoints in the Teneligliptin and Control Groups
| Variable | Teneligliptin Group (n = 8) | Control Group (n = 9) | Between-Group Difference | ||
|---|---|---|---|---|---|
| Mean ± SD | P value | Mean ± SD | P value | P value | |
| A. Ultrasonographic findings | |||||
| Flow-mediated dilation (%) | |||||
| 0 W | 4.0 ± 2.0 (n = 8) | 5.6 ± 2.9 (n = 9) | 0.23 | ||
| 28 W | 7.8 ± 1.6 (n = 8) | 5.6 ± 1.9 (n = 8) | 0.025 | ||
| 28 W-0 W | 3.8 ± 2.1 (n = 8) | 0.001 | −0.3 ± 2.9 (n = 8) | 0.79 | 0.006 |
| Baseline diameter (mm) | |||||
| 0 W | 4.8 ± 0.7 (n = 8) | 4.4 ± 1.0 (n = 9) | 0.39 | ||
| 28 W | 4.1 ± 0.6 (n = 8) | 3.9 ± 0.8 (n = 8) | 0.66 | ||
| 28 W-0 W | −0.7 ± 0.2 (n = 8) | <0.001 | −0.4 ± 0.7 | 0.13 | 0.30 |
| E/A | |||||
| 0 W | 1.3 ± 1.2 (n = 7) | 1.3 ± 1.2 (n = 7) | 0.94 | ||
| 28 W | 1.1 ± 0.6 (n = 7) | 0.8 ± 0.1 (n = 6) | 0.36 | ||
| 28 W-0 W | −0.2 ± 0.6 (n = 7) | 0.40 | −0.1 ± 0.3 (n = 6) | 0.60 | 0.60 |
| E/e’ | |||||
| 0 W | 18.1 ± 9.3 (n = 8) | 18.9 ± 7.2 (n = 9) | 0.86 | ||
| 28 W | 17.6 ± 7.2 (n = 8) | 16.6 ± 10.2 (n = 8) | 0.83 | ||
| 28 W-0 W | −0.5 ± 4.4 (n = 8) | 0.74 | −1.2 ± 5.0 (n = 8) | 0.54 | 0.80 |
| Plaque area (mm2) | |||||
| 0 W | 7.0 ± 2.4 (n = 5) | 5.2 ± 1.2 (n = 2) | 0.39 | ||
| 28 W | 6.8 ± 2.5 (n = 4) | 4.7 ± 1.7 (n = 2) | 0.36 | ||
| 28 W-0 W | −0.3 ± 0.3 (n = 4) | 0.13 | −0.5 ± 0.5 (n = 2) | 0.37 | 0.51 |
| B. Metabolic variables | |||||
| Fasting plasma glucose (mg/dL) | |||||
| 0 W | 128.1 ± 13.1 (n = 8) | 127.0 ± 30.3 (n = 9) | 0.92 | ||
| 28 W | 121.3 ± 17.5 (n = 7) | 142.9 ± 42.5 (n = 8) | 0.23 | ||
| 28 W-0 W | −7.3 ± 10.0 (n = 7) | 0.10 | 24.4 ± 37.8 (n = 8) | 0.11 | 0.05 |
| Hemoglobin A1c (%) | |||||
| 0 W | 6.8 ± 0.1 (n = 8) | 7.0 ± 0.2 (n = 9) | 0.07 | ||
| 28 W | 6.4 ± 0.4 (n = 8) | 7.0 ± 0.7 (n = 8) | 0.08 | ||
| 28 W-0 W | −0.4 ± 0.3 (n = 8) | 0.012 | −0.1 ± 0.6 (n = 8) | 0.83 | 0.19 |
| Triglyceride (mg/dL) | |||||
| 0 W | 98.7 ± 37.7 (n = 7) | 176.2 ± 121.0 (n = 9) | 0.13 | ||
| 28 W | 149.6 ± 107.2 (n = 7) | 143.6 ± 77.4 (n = 8) | 0.90 | ||
| 28 W-0 W | 59.0 ± 93.4 (n = 6) | 0.18 | −8.1 ± 53.4 (n = 8) | 0.68 | 0.11 |
| LDL-cholesterol (mg/dL) | |||||
| 0 W | 107.9 ± 38.3 (n = 8) | 91.7 ± 44.1 (n = 9) | 0.43 | ||
| 28 W | 82.8 ± 23.4 (n = 8) | 87.9 ± 22.2 (n = 8) | 0.66 | ||
| 28 W-0 W | −25.1 ± 28.1 (n = 8) | 0.040 | −5.0 ± 29.4 (n = 8) | 0.65 | 0.18 |
| HDL-cholesterol (mg/dL) | |||||
| 0 W | 53.0 ± 14.8 (n = 8) | 46.7 ± 11.2 (n = 9) | 0.33 | ||
| 28 W | 50.9 ± 9.4 (n = 8) | 50.4 ± 10.5 (n = 8) | 0.92 | ||
| 28 W-0 W | −2.1 ± 9.8 (n = 8) | 0.56 | 1.8 ± 6.6 (n = 8) | 0.48 | 0.37 |
| 8-OHdG (ng/mg creatinine) | |||||
| 0 W | 11.3 ± 4.1 (n = 8) | 7.7 ± 2.5 (n = 9) | 0.042 | ||
| 28 W | 9.3 ± 2.4 (n = 8) | 7.6 ± 1.6 (n = 8) | 0.11 | ||
| 28 W-0 W | −1.9 ± 2.6 (n = 8) | 0.07 | −0.3 ± 2.2 (n = 8) | 0.67 | 0.21 |
Abbreviations: LDL, low-density lipoprotein; HDL, high-density lipoprotein; 8-OHdG, 8-hydroxydeoxyguanosine.