Figure 2.

Muscle biopsies from patients with MSP and MSP‐like disorders. Muscle biopsies from patients with VCP (A‐C), HNRNPA1 (D‐F), SQSTM1 + TIA1 (G‐I), and HSPB8 (J‐L) mutations. H&E‐stained sections show multiple fibers harboring rimmed vacuoles (arrows, A, D, G, and J). Congo red‐stained sections revealed small sarcoplasmic congophilic inclusions (arrowheads, B, E, H, and K). Immunohistochemical stains demonstrate TDP43‐positive sarcoplasmic inclusions (arrowheads, C and F) and punctate TIA1 sarcoplasmic reactivity (arrowheads, I and L).