SUPPLEMENTARY TABLE. 2: Plasma cytokine profiles (pg/mL) in COVID-19 patients at baseline (D 1) versus day 28 (D 28).
| Groups | Ixekizumab | IL-2 | Colchicine | SOC | |
|---|---|---|---|---|---|
| IFN- γ | D 1 | 2.92 (1.81-74.19) | 44.73 (4.13-85.33) | 3.90 (2.21-17.91) | 2.92 (1.90-8.65) |
| D 28 | (n=5) | (n=2) | (n=4) | (n=3) | |
| 4.90 (1.56-25.17) | 4.29 (3.68-4.90) | 2.17 (1.20-13.77) | 1.90 (0.81-10.57) | ||
| (n=5) | (n=2) | (n=4) | (n=3) | ||
| p-value | >0.999 | n too small | 0.2500 | 0.999 | |
| IL-1 β | D1 | 24.19 (10.82-64.50) | 40.24 (5.46-75.01) | 10.25 (1.73-38.49) | 9.78 (1.31-51.44) |
| (n=3) | (n=4) | (n=4) | (n=3) | ||
| D 28 | 0.53 (0.53-1.06) | 14.17 (6.47-21.87) | 4.63 (0.71-31.73) | 13.28 (1.96-37.09) | |
| (n=3) | (n=2) | (n-=4) | (n=3) | ||
| p-value | 0.2500 | n too small | 0.6250 | >0.999 | |
| IL-4 | D 1 | 1.94 (1.10-2.96) | 2.38 (1.78-11.54) | 2.63 (1.70-3.54) | 0.97 (0.40-2.65) |
| (n=7) | (n=3) | (n=6) | (n=6) | ||
| D 28 | 1.49 (0.40-3.54) | 2.31 (0.82-31.16) | 1.10 (0.51-3.26) | 2.07 (1.45-4.22) | |
| (n=7) | (n=3) | (n=6) | (n=6) | ||
| p-value | 0.2969 | >0.9999 | 0.5625 | 0.4375 | |
| IL-6 | D 1 | 23.93 (4.20-88.66) | 4.21 (0.31-8.11) | 4.83 (2.11-16.44) | 2.39 (0.50-6.96) |
| (n=5) | (n=2) | (n=4) | (n=4) | ||
| D 28 | 7.72 (0.24-19.82) | 0.63 (0.41-0.85) | 0.76 (0.39-1.63) | 1.02 (0.46-1.64) | |
| (n=5) | (n=2) | (n=4) | (n=4) | ||
| p-value | 0.3125 | n too small | 0.125 | 0.500 | |
| IL-10 | D 1 | 12.96 (5.06-60.99) | 5.22 (2.13-9.01) | 7.57 (2.19-15.08) | 3.80 (2.00-5.02) |
| (n=5) | (n=3) | (n=4) | (n=5) | ||
| D 28 | 2.08 (1.14-13.50) | 7.36 (6.75-32.43) | 1.69 (1.01-3.40) | 3.99 (2.17-4.93) | |
| (n=5) | (n=3) | (n=4) | (n=5) | ||
| p-value | 0.0625 | 0.2500 | 0.1250 | >0.9999 | |
| IL-18 | D 1 | 385.20 (71.01-482.40) | 139.10 (125.80-547.70) | 234.50 (207.00-259.20) | 185.30 (104.80-298.10) |
| (n=7) | (n=3) | (n=6) | (n=6) | ||
| D 28 | 366.60 (256.40-822.10) | 284.90 (230.00-311.10) | 231.20 (168.10-273.40) | 131.50 (77.89-297.00) | |
| (n=7) | (n=3) | (n=6) | (n=6) | ||
| p-value | 0.4694 | >0.9999 | 0.8438 | 0.8438 | |
| MCP-1 | D 1 | 295.80 (139.10-361.70) | 199.40 (174.40-224.30) | 292.10 (213.80-338.10) | 178.90 (159.00-333.90) |
| (n=7) | (n=2) | (n=6) | (n=5) | ||
| D 28 | 303.30 (224.30-661.40) | 216.90 (197.80-235.90) | 235.60 (158.60-354.10) | 230.00 (119.20-238.90) | |
| (n=7) | (n=2) | (n=6) | (n=5) | ||
| p-value | 0.3750 | n too small | 0.3125 | 0.4375 |
Data are presented as the Median and Interquartile Range (IQR). Comparisons between baseline (D1) and D28 using Wilcoxon matched-pairs rank test, p>0.05. It was not possible to analyze cytokine values from patients treated with low doses of IL-2 because of the small sample size.