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RU38486 reversed short-term chronic unpredictable stress–induced postsurgical pain. Mechanical allodynia test (A, B) and cold allodynia test (C, D) were determined in ipsilateral paws (A, C) and contralateral paws (B, D). Results are expressed as mean ± SEM. *P < .05, **P < .01 vs the corresponding time points in the incision plus stress group with vehicle (n = 10/group).
