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. 2023 Mar 6;192(2):247–264. doi: 10.1093/toxsci/kfad022

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 9. — Mouse PCN were pretreated with MK-801 or perampanel before exposure to H₂S. Intracellular Ca²⁺ levels were measured, and synchronous Ca²⁺ oscillations were analyzed. A, Traces of Ca²⁺ oscillations were shown. Inhibitors for NMDA receptor and AMPA receptor failed to antagonize H₂S-induced suppression of SCO in Phase 2 (A). B, Analysis of SCO in H₂S exposed PCN. MK-801 failed to prevent H₂S-induced effects on peak counts in Phases 1 and 2 (Bi and Bii). Perampanel significantly prevented H₂S-induced increase in peak counts in Phase 1 (Biii) but worsened H₂S-induced decrease in peak counts in Phase 2 (Biv). N = 3. Values are presented as mean ± standard deviation. ANOVA with post hoc Tukey HSD test was performed for statistical significance. Asterisks indicate significant differences compared to vehicle group. *p < .05 and ***p < .001. Abbreviations: H₂S, hydrogen sulfide; PCN, primary cortical neuronal coculture; SCO, synchronous calcium oscillation.