Table 1.
Case 1 | Case 2 | Case 3 | Controls | |
---|---|---|---|---|
Age at symptom onset (y) | 62 | 58–60 | 81 | N/A |
Age at death (y) | 68 | 67 | 84 | 72.7SD 17.6 |
AV-45 findings | Positive for amyloid | Positive for amyloid | Positive for amyloid | N/A |
AV-133 findings | Bilateral caudate and putamen dopaminergic depletion | Normal | Dopaminergic depletion in center putamen and 3/5 readers noted a decrease in right putamen as well | N/A |
Clinical diagnosis at PET imaging | DLB | AD | DLB | N/A |
Clinicopathological diagnosis | DLB and AD | DLB and AD | MSA and AD | Cognitively normal |
Time between symptoms and imaging | 5 y | 5 y | 3 y | N/A |
Time between PET imaging and death | 22 mo | 30 mo | 1–2 wk | N/A |
Postmortem interval | 3.0 h | 3.1 h | 2.5 h | 4.0 h SD 0.8 |
NIA-AA ADNC | High ADNC | Intermediate ADNC | Intermediate ADNC | Not AD (1) Low AD (2) |
Lewy body stage | Neocortical | Neocortical | N/A (MSA) | All Stage 0 |
NIA-AA ADNC, National Institute on Aging-Alzheimer’s Association Alzheimer’s Disease Neuropathological Change Level; Lewy body stage, Unified Staging System for Lewy Body Disorders stage level; N/A, not applicable.