Table 6.
Neurological Sequalae
| Neurological Sequalae | Arm 1 | Arm 2 | Arm 3 |
|---|---|---|---|
| n = 20 | n = 15 | n = 16 | |
| Inflammatory myelopathy | … | 1 | … |
| Anterior cord ischemia | … | 1 | … |
| Radiculopathy/arachnoiditis | … | … | 1 |
| New-onset lower limb weaknessa | 1 | … | … |
| Clinical presentation of stroke | 0 | 2 | 1 |
| New isolated cranial nerve palsy | 0 | 1 | 0 |
| New onset seizures | 5 | 2 | 3 |
| IRIS [27] recorded by day 56 (of which neurological IRIS [28]) | 2 (1) | 2 (2) | 3 (2) |
Few IRIS events occurred (arm 1, 2; arm 2, 2; arm 3, 3), of which 4 of 7 were defined as neurological IRIS. Within the first 56 days of treatment, 4 participants developed new-onset lower limb weakness (tuberculosis myelopathy, 2; tuberculosis radiculomyelopathy/arachnoiditis, 1; other [no cause found prior to death], 1); 3 participants developed new-onset hemiplegia; 1 patient developed new-onset isolated cranial nerve palsy (lower motor neuron VII). Thirteen participants presented with new-onset seizures at tuberculous meningitis diagnosis. An additional 9 participants had new-onset seizures within the first 2 months of follow-up (arm 1, 5; arm 2; 2; arm 3, 2; P = .54).
Abbreviation: IRIS, immune reconstitution inflammatory syndrome.
No cause found prior to death.