Table 4.

Subthreshold group differences (that did not survive multiple comparisons corrections) in cortical volume, surface area and thickness, and subcortical volumes, using the Desikan–Killiany atlas, including sex and age as covariates.

Region	% change in individuals with AAD	P-value	P-value corrected for ICV
Total brain volume	−4.3	0.026	N/A
ICV	−4.1	0.042	N/A
Cortical volume
Left fusiform	−6.6	0.017	0.119
Left inferior parietal	−6.6	0.042	0.201
Left isthmus cingulate	−8.1	0.018	0.149
Left pars opercularis	−10.5	0.009	0.040
Left superior parietal	−6.4	0.044	0.252
Right superior parietala	−6.8	0.039	0.253
Left supramarginal	−10.3	0.003	0.020
Right supramarginala	−8.4	0.010	0.088
Left parahippocampal	−7.0	0.029	0.099
Right parahippocampal	−5.9	0.035	0.164
Right entorhinal	−7.7	0.022	0.036
Right medial orbitofrontal	−7.2	0.003	0.031
Right middle temporal	−6.8	0.034	0.279
Right precentral	−5.9	0.018	0.143
Right precuneus	−6.0	0.045	0.377
Cortical surface area
Left isthmus cingulate	−7.9	0.012	0.107
Left lateral orbitofrontal	−5.9	0.008	0.074
Left pars opercularis	−8.7	0.020	0.076
Right medial orbitofrontal	−5.5	0.016	0.153
Left supramarginal	−8.6	0.007	0.043
Right supramarginal	−6.7	0.019	0.171
Cortical thickness
Left entorhinal	−2.3	0.047	0.055
Left inferior parietal	−2.5	0.006	0.006
Left superior parietal	−2.3	0.021	0.046
Right entorhinal	−3.7	0.017	0.005
Right pars triangularis	−2.4	0.040	0.022
Subcortical volume
Left thalamus	−4.5	0.013	0.129
Right thalamus	−4.4	0.014	0.153

We calculated the % change in size of the atlas regions between groups. The column to the right displays P-values for these models while additionally including ICV as a covariate. P-values in bold are significant also when correcting for ICV.

^aInteraction between group and sex for these regions.