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. 2022 Oct 10;41(4):552–559. doi: 10.1038/s41587-022-01489-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — U2OS and HeLa cells were transiently transfected with H2B-rig.-rsEGFP2 and stained with SiR-DNA before live cell confocal imaging. (a) The localization of rigidly fused H2B-rsEGFP2 correlates with chromatin structures and additional accumulation in nucleoli. Nucleoli are identified as subnuclear structures with low DNA but high protein density, which are surrounded by areas of high DNA density. (b) H2B-rsEGFP2 stays associated with DNA in condensed chromosomes during mitosis. Scale bar 5 μm.