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. 2023 Apr 9;20(5):689–701. doi: 10.7150/ijms.76580

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Histones H3 promotes HCC cells proliferation and metastasis in vivo Tumor growth curves (A) and representative H&E staining (B) shown after stable histones H3-expressing cells were engrafted in flanks of BALB/c nude mice. *P<0.05, ****P<0.0001. (C) showed luciferase signal of control cells (the left flank) and stable histones H3-expressing cells (the right flank) in one BALB/c nude mice. Lung metastasis experiments were performed by tail vein injection model. Statistical table of pulmonary metastasis (D), representative luciferase (E) signal images and H&E staining of lung tissues (F) were presented.