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. 2023 Apr 17;13:6256. doi: 10.1038/s41598-023-33086-2

Figure 3.

Figure 3

SGLT2 inhibition increases cell proliferation and down-regulates the cell cycle regulatory proteins expression altered by NPs exposure. (a) Cell proliferation of PCAECs treated with or without NPs (10 μg/mL) alone or with ENA (0.01, 0.1, 1 μM) for 24 h. Data are the mean ± SEM (n = 6). *p < 0.05; **p < 0.01 vs. PC (complete media + NPs 10 μg/mL); ##p < 0.01 vs. NC (complete media). (b-c) Representative immunoblots for cell cycle regulatory proteins: p53 and p21 (lower band) with their corresponding cumulative data. Data are the mean ± SEM (n = 3–4). *p < 0.05 versus PC; #p < 0.05 versus NC.