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. 2023 Apr 17;14:2196. doi: 10.1038/s41467-023-37975-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Significantly altered viral taxa at (a) 6-week and (b) 6-month compared to baseline using MaAsLin2 (adjusted for age, gender, treatment regimens, drug durations, and the number of raw reads; baseline was set as reference group). Coefficient was obtained from MaAslin2 output and only those significantly altered taxa were presented (original p < 0.05 with qval < 0.15). Positive coefficient value represented viral taxa enriched at 6-week or 6-month, while negative coefficient value represented viral taxa enriched at baseline. The number following the species name suggested the prevalence of the bacteriophage. (#qval < 0.15, *pqval < 0.05, **qval < 0.01, ***qval < 0.001, ****qval < 0.0001; all original pval < 0.05).