Figure 2.

GABA_A receptor-mediated inhibition in CA1 pyramidal neurons of Ube3a^m−/p+ mice. (A) Representative recording traces of miniature inhibitory postsynaptic currents (mIPSCs) in CA1 pyramidal neurons of wild-type (WT) and Ube3a^m-/p+ mice. (B–C) Comparison of the mIPSC frequency (B) and amplitude (C) between WT (n = 9 cells) and Ube3a^m−/p+ (n = 10 cells) groups. (D) Representative current traces for evaluating tonic GABA_A receptor-mediated inhibition in CA1 pyramidal neurons. The tonic current amplitude was determined as the baseline current shift induced by focal application of SR95531 (10 μM). € Comparison of the tonic current amplitudes in WT (n = 10 cells) and Ube3a^m−/p+ (n = 9 cells) mice. The tonic form of inhibition is significantly decreased in the Ube3a^m−/p+ group. Data are presented as the mean ± SEM, *p < 0.05, ns not significant by the unpaired t test.