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. 2023 Apr 17;13:5685. doi: 10.1038/s41598-023-32376-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of chronic bumetanide administration on behavioral test results in Ube3a^m−/p+ mice. (A) Effects of bumetanide on the results of the novel object recognition test. ns not significant, *p < 0.05; **p < 0.01 by post-hoc analysis after two-way ANOVA. n = 14–16 for each group. (B) Effects of bumetanide on the performance of mice in the accelerating rotarod test. ns notsignificant between treatment with bumetanide (Bum) and vehicle control (Veh). ***p < 0.001; ****p < 0.0001 for wild-type (WT) Veh versus Ube3a^m−/p+ Veh. ####: p < 0.0001 for WT Bum versus Ube3a^m−/p+ Bum by post-hoc analysis after three-way repeated-measures ANOVA. n = 15–18 for each group. (C) Effects of bumetanide on the results in the open field test. The left and right panels show the total distance traveled and ratio time spent in the center region, respectively. ns not significant. *p < 0.05; **p < 0.01; ****p < 0.0001 by post-hoc analysis after two-way ANOVA. n = 15–18 for each group. The open field and rotarod test results are not affected by bumetanide, but bumetanide restores the low discrimination index of Ube3a^m−/p+ mice in the novel object recognition test.