Table 1.
Properties of excitatory and inhibitory synapse transmission onto CA1 pyramidal neurons.
| WT | Ube3am−/p+ | p value | |
|---|---|---|---|
| mEPSC frequency (n/min) | 18.10 ± 3.30 (n = 8) | 7.90 ± 1.40 (n = 8) | < 0.05 |
| mEPSC amplitude (pA) | 11.40 ± 0.63 (n = 8) | 10.46 ± 0.85 (n = 8) | 0.38 |
| mEPSC rise time (ms) | 3.76 ± 0.15 (n = 8) | 3.90 ± 0.15 (n = 8) | 0.51 |
| mEPSC decay (ms) | 4.73 ± 0.28 (n = 8) | 4.66 ± 0.42 (n = 8) | 0.26 |
| PPR for evoked EPSCs | 1.36 ± 0.06 (n = 12) | 1.55 ± 0.09 (n = 10) | 0.22 |
| mIPSC frequency (n/s) | 4.90 ± 0.58 (n = 9) | 4.71 ± 0.50 (n = 10) | 0.81 |
| mIPSC amplitude (pA) | 21.70 ± 1.20 (n = 9) | 20.20 ± 2.30 (n = 10) | 0.61 |
| mIPSC rise time (ms) | 2.69 ± 0.11 (n = 9) | 2.39 ± 0.15 (n = 10) | 0.13 |
| mIPSC decay (ms) | 8.83 ± 0.39 (n = 9) | 7.79 ± 0.77 (n = 10) | 0.26 |
| PPR for evoked IPSCs | 0.78 ± 0.03 (n = 10) | 0.82 ± 0.05 (n = 10) | 0.43 |
mEPSC miniature excitatory postsynaptic current, mIPSC miniature inhibitory postsynaptic current, PPR paired-pulse ratio, WT wild-type.