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. 2023 Feb 28;25(5):479–489. doi: 10.1007/s11912-023-01380-x

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Progress of CAR-T cells in the treatment of solid neoplasms. (a) Evolution of CAR structure and function. (b) Current modifications of CAR-T cells to enhance or repress function. (c) Future directions of CAR-T cell treatment including novel methodologies and gene targets. Created with BioRender.com