Table 1.
Ongoing clinical trials using chimeric antigen receptor T cells (CAR-T) for pediatric solid tumors
| NCT number | Title | Status | Conditions | Locations |
|---|---|---|---|---|
| NCT02932956 | Glypican 3-specific chimeric antigen receptor expressed in t cells for patients with pediatric solid tumors (GAP) | Active, not recruiting | Liver cancer | Texas Children’s Hospital, Houston, TX, USA |
| NCT04377932 | Interleukin-15 armored glypican 3-specific chimeric antigen receptor expressed in t cells for pediatric solid tumors | Recruiting | Liver cancer|rhabdomyosarcoma|malignant rhabdoid tumor|liposarcoma|Wilms tumor|yolk sac tumor | Texas Children’s Hospital, Houston, TX, USA |
| NCT04715191 | Interleukin-15 and interleukin-21 armored glypican-3-specific chimeric antigen receptor expressed in t cells for pediatric solid tumors | Not yet recruiting | Liver cancer|rhabdomyosarcoma|malignant rhabdoid tumor|liposarcoma|Wilms tumor|yolk sac tumor | Texas Children’s Hospital, Houston, TX, USA |
| NCT04897321 | B7-H3-specific chimeric antigen receptor autologous T cell therapy for pediatric patients with solid tumors (3CAR) | Recruiting | Pediatric solid tumor|osteosarcoma|rhabdomyosarcoma|neuroblastoma|Ewing sarcoma|Wilms tumor|adrenocortical cancer|desmoplastic small round cell tumor|germ cell cancer|rhabdoid tumor|clear cell sarcoma|hepatoblastoma|melanoma|carcinoma|malignant peripheral nerve sheath tumors|soft tissue sarcoma | St. Jude Children’s Research Hospital, Memphis, TN, USA |
| NCT04483778 | B7H3 CAR T cell immunotherapy for recurrent/refractory solid tumors in children and young adults | Recruiting | Pediatric solid tumor|germ cell tumor|retinoblastoma|hepatoblastoma|Wilms tumor|rhabdoid tumor|carcinoma|osteosarcoma|Ewing sarcoma|rhabdomyosarcoma|synovial sarcoma|clear cell sarcoma|malignant peripheral nerve sheath tumors|desmoplastic small round cell tumor|soft tissue sarcoma|neuroblastoma|melanoma | Seattle Children’s Hospital, Seattle, WA, USA |
| NCT03618381 | EGFR806 CAR T cell immunotherapy for recurrent/refractory solid tumors in children and young adults | Recruiting | Pediatric solid tumor|germ cell tumor|retinoblastoma|hepatoblastoma|Wilms tumor|rhabdoid tumor|carcinoma|osteosarcoma|Ewing sarcoma|rhabdomyosarcoma|synovial sarcoma|clear cell sarcoma|malignant peripheral nerve sheath tumors|desmoplastic small round cell tumor|soft tissue sarcoma|neuroblastoma | Seattle Children’s Hospital, Seattle, WA, USA |
| NCT03373097 | Anti-GD2 CAR T cells in pediatric patients affected by high risk and/or relapsed/refractory neuroblastoma or other GD2-positive solid tumors | Recruiting | Neuroblastoma|neuroblastoma recurrent|GD2-positive solid tumors|osteosarcoma|Ewing sarcoma|sarcoma | Ospedale Pediatrico Bambino GesÃ1, Roma, Italy |
Table data generated October 17, 2022, from ClinicalTrials.gov