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. 2022 Nov 17;72(5):1327–1335. doi: 10.1007/s00262-022-03327-w

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — STING-dependent gene expression differences between MC38 and B16F10 tumors. A Volcano plots comparing gene expression changes in STING KO mice as a Log2 Fold change relative to wild-type mice in MC38 (left) and B16F10 (right) tumors, as determined by Nanostring. B Heatmap of top differentially expressed genes (|Log2 FC| ≥ 2; FDR ≤ 0.05) from (A). C Time course of IFN signature (CMPK2, HERC5, IFIT1, MX1, CD274, CXCL10) changes in B16F10 and MC38 tumors implanted into WT or STING KO mice and analyzed at day 8 or day 15 by Fluidigm