Skip to main content
. 2023 Mar 13;324(5):R635–R644. doi: 10.1152/ajpregu.00189.2022

Figure 1.

Figure 1.

Signaling. A: body weights of male wild-type (WT, n = 19), male GLP-1R KO (n = 21), female WT (n = 11), and female GLP-1R KO (n = 21) mice before experimentation two-way ANOVA with Tukey’s multiple comparisons (****P < 0.0001: male vs. female). B: conditioned taste avoidance (CTA) assay in male WT and GLP-1R KO mice conditioned to saline or 2.5 mg/kg DON (n = 8–10). Food intake (FI) test in WT and GLP-1R KO male (n = 8–10; C) and female (n = 9–10; D) mice fasted for 4–5 h and injected with 2.5 mg/kg DON compared with WT saline (**P < 0.01, ***P < 0.001, ****P < 0.0001) and compared with KO saline (#P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001) by two-way ANOVA with Tukey’s multiple comparison test. E: body weights of WT and Gcg KO male and female mice (n = 19–20) two-tailed Student’s t test; no significant differences. F: CTA assay in male and female WT and Gcg KO mice conditioned to saline or 2.5 mg/kg DON compared with WT saline (**P < 0.01, ***P < 0.001, ****P < 0.0001) and compared with KO saline (#P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001) (n = 4–14). G: food intake test in WT and Gcg KO male and female mice (n = 4–14) compared with WT saline (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) and compared with KO saline (#P < 0.05, ##P < 0.01, ###P < 0.001, ####P < 0.0001) by two-way ANOVA with Tukey’s multiple comparison test. All data are represented as means ± SE. DON, deoxynivalenol; Gcg, preproglucagon gene; KO, knockout.