Table 1.
Demographic details, symptoms at presentation and CSF parameters for all patients who underwent an eye exam
| Demographic characteristics | N=44 (%) |
|---|---|
| Gender, females | 15 (34) |
| Median Age in years at first eye exam (IQR) | 56 (44-64) |
| Ethnicity: Asian | 4 (9) |
| African American | 2 (4.5) |
| Caucasian | 35 (80) |
| Hispanic | 2 (4.5) |
| Biracial | 1 (2) |
| Location Midwest US | 1 (2) |
| NE US | 16(36) |
| SE US | 17 (39) |
| W Coast US | 10(23) |
| Species (n=39) | |
| Neoformans | 29 (74%) |
| Gattii | 10 (26%) |
| GMCSF auto Ab (n=34) | 6(18%) |
| Median CD 4 count (IQR) | 452 (304-769) |
| Underlying conditions | |
| Diabetes | 5(11) |
| Hypertension | 22(50) |
| No. shunted at the time of eye exam | 13 |
| Time in weeks from CM diagnosis to eye exam (IQR) | 12 (5-21) |
| Disease presentation | |
| Fever | 13(30) |
| Headache | 40 (91%) |
| Worsening mental status | 16 (36%) |
| Hearing loss | 21 (48%) |
| Vision change | 27 (61%) |
| Nausea and vomiting | 25 (57%) |
| Falls | 4 (9%) |
| Dizziness | 11(25%) |
| Gait instability | 9 (20%) |
| CSF parameters | Median (IQR) |
| Cryptococcal antigen titer (n=44) | 1:64(1:1-1:256) |
| Opening pressure (cm CSF) (n=43) | 20 (15-28) |
| Glucose (mg/dL) (n=44) | 47(29-56) |
| Protein (mg/dL) (n=43) | 84 (57-199) |
| WBC (/mm3) (n=42) | 39(14-91) |