Figure 2.

Diagram of signaling pathways related to STAT3 and macrophage polarization. STAT3 influence macrophage polarization through different signaling pathways. The major pathway associated with STAT3 is JAK/STAT signaling pathway, and SOCS, PIAS and PTP can inhibit different targets of this signaling pathway, which ultimately affects the direction of macrophage polarization. The NF-κB signaling pathway, PI3K/AKT signaling pathway, Notch signaling pathway, Hedgehog signaling pathway, Wnt signaling pathway and MAPK signaling pathway crosstalk with JAK/STAT3 signaling pathway, which regulates gene transcription and have effects on macrophage polarization.