Table 1.
Regulation of macrophage polarization by targeting STAT3 for the treatment of related diseases.
| Disease classification | Disease | Experimental Model | Related signaling pathway | Impact on STAT3 | Phenotype promoted | Affect | Reference |
|---|---|---|---|---|---|---|---|
| Inflammatory immunological disorder | Pancreatitis | Rat | JAK2/STAT3↓ | ↓ | M2 | Reduced pancreatic inflammation | (40) |
| Myocardial ischaemia/ reperfusion injury |
Rat | JAK2/STAT3↓ | ↓ | M2 | Inhibited cardiac apoptosis and reduced inflammation | (41) | |
| Psoriasis | Mouse | JAK/STAT3↓ | ↓ | M2 | Alleviated the hyperkeratotic epidermis and reduced inflammation | (42) | |
| Atopic dermatitis | Mouse | JAK2/STAT3↑ | ↑ | M2 | Ameliorated skin lesion and reduced inflammation | (44) | |
| Gouty arthritis | Rat | JAK2/STAT3↑ | ↑ | M2 | Reduced arthritis inflammation | (45) | |
| Non-alcoholic steatohepatitis (gut-liver axis) |
Mouse | IL-10/(JAK)/STAT3↑ | ↑ | M2 | Alleviated barrier dysfunction and mitigated bacterial translocation | (58) | |
| Rheumatoid arthritis (RA) | Macrophage of RA patients | IL-10/(JAK1)/STAT3↑ | ↑ | M2 | Inhibited inflammatory cytokines and increased phagocytosis | (59) | |
| Nephritis | a. Rat’s bone marrow-derived macrophage b. Rat |
SOCS3↓ | ↑ | M2 | Reduced inflammation | (66) | |
| Diabetic wounds | a. Human umbilical cord mesenchymal stromal cell and macrophage b. Rat |
NF-κB↓ AKT↑ |
↑ | M2 | Reduced inflammation and promoted wound healing | (80) | |
| Cancer | Colorectal cancer | a. Human colorectal cancer cell and macrophage b. Mouse |
JAK2/STAT3↓ | ↓ | M1 | Inhibited colorectal cancer cells proliferation and migration Inhibited tumor growth and metastasis |
(43) |
| Wnt5a↓ | ↓ | M1 | (119) | ||||
| Gastric cancer | a. Human gastric cancer cell b. Mouse |
IL-(6/8)/JAK2/STAT3↓ | ↓ | M1 | Inhibited gastric cancer cells migration, invasion and epithelial-mesenchymal transition Inhibited intratumor proliferation and angiogenesis |
(55) | |
| Non-small-cell lung cancer (NSCLC) | a. Human NSCLC cell and macrophage b. Mouse |
JAK(1/2)/STAT(3/6)↓ | ↓ | M1 | Inhibited NSCLC cells proliferation and migration Inhibited tumor growth and metastasis |
(48) | |
| Ovarian Cancer | Human ovarian cancer cell and macrophage | IL-6/JAK2/STAT3↓ | ↓ | M1 | Inhibited IL-6 Secretion of ovarian cancer cells |
(46) | |
| Gliomas | a. Human glioma cell and macrophage b. Mouse |
IL-6/JAK2/STAT3↓ | ↓ | M1 | Inhibited tumor cells clone formation, migration, invasion and tube formation in vascular endothelial cells | (47, 49) | |
| Breast cancer | a. Human breast cancer cell and macrophage b. Mouse |
SOCS3↑ | ↓ | M1 | Inhibited breast cancer cell invasion, the tumor growth and metastasis | (69) | |
| JAK2/STAT3/Notch↓ | ↓ | M1 | (109) | ||||
| Pancreatic adenocarcinoma | Mouse | NF-κB↓ | ↓ | M1 | Inhibited proangiogenic and tumor-promoting activity | (81) | |
| Liver cancer | a. Human liver cancer cell and macrophage b. Mouse |
NF-κB↓ | ↓ | M1 | Inhibited the proliferative, invasive, and migratory ability of liver cancer | (86) | |
| Bladder cancer | a. Murine bladder cancer cell and macrophage b. Mouse |
PI3K/AKT↓ | ↓ | M1 | Inhibited bladder tumor cell growth | (100) | |
| Lung carcinoma Melanoma |
a. Murine cancer cell and macrophage b. Mouse |
MAPK/ERK↓ | ↓ | M1 | Inhibited tumor cell proliferation and tumor angiogenesis | (124) | |
| Fibrosis | Cardiac fibrosis | Rat | PI3K/AKT↑ | ↑ | M2 | Promoted wound healing and attenuated myofibroblast infiltration | (97) |
| Pulmonary fibrosis | a. Murine lung ATII-like epithelial cell and macrophage b. Mouse |
Shh/Gli↓ | ↓ | M1 | Inhibited pulmonary fibrosis | (113) | |
| Kidney Fibrosis | a. Murine macrophage b. Mouse |
Wnt3a/β-catenin↓ | ↓ | M1 | Ameliorated kidney fibrosis | (116) |
↓ means inhibition; ↑ means promotion.