Table 3.
Effect of tardive dyskinesia status, smoking status, the two SNPs and their interaction on Aligned Rank Transform of Abnormal Involuntary Movement Scale tardive dyskinesia score
| Effect | F | P value | Power (%) |
|---|---|---|---|
| Tardive dyskinesia status | F(1,148) = 75.39 | 6.5 × 10−15# | 100.0 |
| Smoking | F(2,148) = 16.34 | 3.9 × 10−7# | 100.0 |
| rs1076560 | F(2,148) = 2.33 | 0.10 | 46.6 |
| rs4680 | F(2,148) = 3.27 | 0.04# | 61.4 |
| Tardive dyskinesia status*Smoking | F(2,148) = 5.36 | 0.01# | 83.5 |
| Tardive dyskinesia status* rs1076560 | F(2,148) = 0.07 | 0.93 | 6.1 |
| Smoking* rs1076560 | F(3,148) = 3.57 | 0.02# | 78.0 |
| Tardive dyskinesia status* rs4680 | F(2,148) = 1.46 | 0.24 | 30.8 |
| Smoking* rs4680 | F(4,148) = 5.35 | 4.7 × 10−4# | 97.0 |
| rs1076560*rs4680 | F(4,148) = 7.53 | 1.5 × 10−5# | 99.6 |
| Tardive dyskinesia status*Smoking* rs4680 | F(2,148) = 0.38 | 0.68 | 11.0 |
| Tardive dyskinesia status*Smoking* rs1076560 | F(1,148) = 0.59 | 0.44 | 11.9 |
| Tardive dyskinesia status* rs1076560*rs4680 | F(3,148) = 2.72 | 0.05# | 65.1 |
| Smoking* rs1076560*rs4680 | F(2,148) = 15.29 | 9.2 × 10−7# | 99.9 |
| Tardive dyskinesia status*Smoking* rs1076560*rs4680 | F(1,139) = 0.60 | 0.44 | 12.0 |
The main effects of tardive dyskinesia status, Smoking and rs4680 were found to significantly affect AIMSart tardive dyskinesia score. The interactions of tardive dyskinesia status*Smoking, Smoking*rs1076560, Smoking*rs4680, tardive dyskinesia status* rs1076560*rs4680 and smoking* rs1076560*rs4680 withstood Bonferroni multiple comparisons post-ANOVA.
ANOVA, analysis of variance; SNP, single nucleotide polymorphism.
#P value < 0.05.