Table 2.
Antibacterial activity of individual or combined treatment with OligoG, ampicillin and/or ciprofloxacin on H. influenzae in mature biofilms
| Ampicillin (mg/L) alone or combined with OligoG (64 g/L) |
Ciprofloxacin (mg/L) alone or combined with OligoG (64 g/L) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Strain | Parameter | OligoG (g/L) | Individual treatment | Combined treatment | Ratiob | Individual treatment | Combined treatment | Ratiob |
| Hi-022 | MBIC | ≤16 | >500a | ≤4 | ≥125* | ≤0.03 | ≤0.03 | Indeterminate |
| MB2LDC | >64 | >500a | >500 | Indeterminate | >1 | ≤0.03 | ≥32* | |
| BBC | >64 | >500a | >500 | Indeterminate | >1 | 0.5 | ≥2 | |
| Hi-072 | MBIC | 32 | 4 | ≤0.5 | ≥8* | 1 | ≤0.5 | ≥1 |
| MB2LDC | >64 | >64 | >64 | Indeterminate | >16 | >16 | Indeterminate | |
| BBC | >64 | >64 | >64 | Indeterminate | >16 | >16 | Indeterminate | |
Asterisk indicates significant decrease (ratio ≥8).44
a
For technical reasons, the highest concentration tested was 500 mg/L (i.e. deviating from the standardized 2-fold scale)
b
Ratio of MBIC, MB2LDC or BBC by individual treatment to the same parameter by combined treatment.