TABLE 2.

Characteristics of neutrophil-derived extracellular vesicles (EV)

	Release	Shape	Size	In tissue	Organelle cargo
Exosomes	Multivesicular body fusion with plasma membrane	Spherical	50–150 nm	Blood	–
Ectosomes	Bud off from cell surface	Spherical	100–1000 nm	Blood	–
Small apoptotic EVs	Similar to exo/ectosomes	Spherical	50–150 nm	Blood	–
Large apoptotic EVs or apoptotic bodies	Bud off from cell surface, detachment of apoptopodia or beaded apoptopodia	Spherical	1–5 μm		–
Cytoplast	Neutrophil extracellular trap NET release	Spherical	1–5 μm	Blood, bronchoalveolar fluid	Fragments of organelles
Elongated neutrophil-derived structures (ENDS)	Tether detachment from rolling neutrophils	Elongated, spherical	Median 7 μm long and 115 nm thick	Blood	–
Migrasomes	Vesicle formation at the tip or branching point	Spherical	2–3 μm	Trachea, lung, liver, Blood	Smaller vesicles
Mitosomes	of traction fibers or migrating neutrophils		2–3 μm	Blood, liver, spleen	Damaged mitochondria