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. 2023 Mar 31;11:1134121. doi: 10.3389/fcell.2023.1134121

FIGURE 5.

FIGURE 5

The Artemis inhibitor 827171 and DNA-PK inhibitor AZD7648 substantially inhibit proliferation of B-ALL. Primary B-ALL cells (BLQ5, LAX56, and LAX7R) were transduced with GFP, and 100,000 cells were plated in 24-well plates seeded with irradiated OP9 cells. Cells were treated with DMSO control (A), Artemis inhibitor 827171 (B–D) or DNA-PK inhibitor AZD7648 (E–G) with the indicated doses. Green fluorescence intensity was measured by Incucyte every 8 h. Raw values were normalized to the 0 h DMSO control. The dashed lines indicate the mean of the final time point measurements of the DMSO control for each primary B-ALL cell. The statistical analysis of proliferation differences is shown for the final time point measurements for BLQ5 (H), LAX56 (I), LAX7R (J), after treatment with 827171 or DNA-PK inhibitor AZD7648 at indicated doses compared to DMSO control. ns: non-significant. *p < 0.05; **p < 0.001; ***p < 0.0001, one-way ANOVA.