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. 2023 Apr 17;6(4):e238655. doi: 10.1001/jamanetworkopen.2023.8655

Table 2. Comparison of Outcomes Between Methimazole-Treated and Propylthiouracil-Treated Patients With Thyroid Storm.

Outcome Methimazole (n = 727) Propylthiouracil (n = 656) Difference P value
Unadjusted Adjusted
Composite of in-hospital death or discharge to hospice (95% CI), % 6.3 (4.6 to 8.1) 8.5 (6.4 to 10.7) 2.2 (−0.6 to 5.0) 0.6 (−1.8 to 3.0) .64
In-hospital death (95% CI), % 5.0 (3.4 to 6.5) 7.9 (5.9 to 10.0) 3.0 (0.4 to 5.6) 1.1 (−1.2 to 3.5) .34
Discharge to hospice (95% CI), % 1.4 (0.5 to 2.2) 0.6 (0.0 to 1.2) −0.8 (−1.8 to 0.3) −0.6 (−1.6 to 0.3) .20
Organ support–free days, mean (95% CI) 19.0 (18.6 to 19.4) 18.2 (17.7 to 18.7) −0.8 (−1.4 to −0.2) −0.2 (−0.7 to 0.3) .40
Total cost of thionamide, mean (95% CI), $ 58 (51 to 65) 143 (115 to 172) 85 (57 to 113) 72 (48 to 97) <.001
Total cost of hospitalization, mean (95% CI), $ 18 068 (16 497 to 19 640) 21 474 (18 973 to 23 976) 3406 (513 to 6299) 1097 (−972 to 3166) .30