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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: J Thromb Haemost. 2022 Dec 22;21(3):522–533. doi: 10.1016/j.jtha.2022.10.027

Figure 5. Knockdown of IL6R or ATXN2L alters inducible fibrinogen synthesis.

Figure 5.

HepG2 cells were transfected with siRNAs against candidate genes in the presence of IL-6, and supernatant and cells were analyzed as in Fig 3. (A) Target gene knockdown. (B) Aα chain in the media. (C) Cell count following treatment with siRNAs that altered fibrinogen synthesis in panel B. (D) FGA, (E) FGB, and (F) FGG expression. All data were normalized to treatment with control siRNA (siNC), N=4–12 for each siRNA, bars indicate mean + standard error of the mean, **P < 0.01, ***P < 0.001, ****P < 0.0001