Table 2. Dementia Hazard by Majority HbA1c Concentration Exposure Stratified by Sexa.
| HbA1c, % of total hemoglobin | Men | Women | ||||
|---|---|---|---|---|---|---|
| Events | Person-years | Adjusted HR (95% CI) | Events | Person-years | Adjusted HR (95% CI) | |
| <6 | 750 | 59 070 | 0.88 (0.81-0.95) | 748 | 40 511 | 1.01 (0.94-1.09) |
| 6 to <7 | 2958 | 219 183 | 0.80 (0.77-0.84) | 3716 | 215 574 | 0.83 (0.80-0.87) |
| 7 to <8 | 1241 | 96 017 | 0.98 (0.93-1.04) | 1428 | 99 768 | 0.86 (0.81-0.91) |
| 8 to <9 | 244 | 28 310 | 0.93 (0.82-1.06) | 304 | 24 900 | 1.06 (0.94-1.19) |
| 9 to <10 | 110 | 13 004 | 1.35 (1.12-1.63) | 100 | 10 514 | 1.10 (0.90-1.34) |
| ≥10 | 416 | 45 561 | 1.70 (1.54-1.88) | 429 | 41 036 | 1.61 (1.46-1.78) |
Abbreviations: HbA1c, glycated hemoglobin; HR, hazard ratio.
SI conversion factor: To convert percentage of total hemoglobin to proportion of total hemoglobin, multiply by 0.01.
a
Cox proportional hazards regression adjusted for age (as time scale), sex, race and ethnicity, baseline hyperglycemic and hypoglycemic events, myocardial infarction, peripheral artery disease, neuropathy, nephropathy, stroke, and retinopathy.