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. Author manuscript; available in PMC: 2023 Apr 18.
Published in final edited form as: Annu Rev Genomics Hum Genet. 2022 Jun 24;23:363–381. doi: 10.1146/annurev-genom-010422-091101

Figure 1.

Figure 1

Distinct pediatric and adult manifestations of short telomere syndromes and their increasing prevalence with age. Short telomere syndromes show a phenotype continuum that is determined by the severity of the telomere length defect relative to age. The colored lines indicate percentiles for telomere length, and the two boxes summarize the common presentations at the extremes of age. Each red circle represents a hypothetical short telomere syndrome patient. The red shaded region indicates the threshold where short telomere length is sufficient to provoke telomere-mediated disease. Abbreviations: AML, acute myeloid leukemia; CH, clonal hematopoiesis; MDS, myelodysplastic syndrome. Telomere length nomogram adapted from Reference 6.