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. 2022 Sep 16;7(7):1225–1240. doi: 10.1182/bloodadvances.2022007652

Figure 4.

Figure 4.

CGD mice have expanded granulopoiesis compared with WT mice in zymosan-induced lung inflammation at 24 hours. WT and CGD mice were challenged with 20 μg intranasal zymosan. BM cells were collected after 24 hours and analyzed by flow cytometry. (A) BM cells per femur were counted. LSK, CMP, GMP, and MEP counts were calculated from flow cytometry results. (B) Cell counts of myeloblast, promyelocyte, myelocyte, and metamyelocyte were calculated from flow cytometry results. n ≥ 7 from 3 independent experiments. Data are means ± SEM. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001, by one-way ANOVA. BM, bone marrow; CMP, common myeloid progenitors; GMP, granulocyte-macrophage progenitor; LSK, Lin−Sca1+c-Kit+; MEP, megakaryocyte-erythrocyte progenitor.