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. 2023 Mar 5;122(7):1376–1389. doi: 10.1016/j.bpj.2023.03.003

Figure 3.

Figure 3

Simulated structures reproduce contacts within DNA segments and interactions between chromosomes and nuclear bodies. (a) Comparison between simulated (bottom triangle) and experimental (top triangle) contact matrix (84). A zoomed-in contact map between chromosomes 2 and 3 is shown with the Pearson’s correlation coefficient (r). (b) Comparison (for chromosome 4) between the model predicted lamin-B DamID and SON TSA-seq signals and the experimental data at 1 MB resolution, with the Pearson’s correlation coefficients shown on the side. The subcompartment annotations at the top of the figure were taken from the IMR90 cell type (fibroblast) (57). (c) Pearson correlation coefficients between simulated and experimental lamin-B DamID (blue) and SON TSA-seq (yellow) data for individual chromosomes. The genome-wide averages are shown as straight lines with the corresponding values on the side. To see this figure in color, go online.