Figure 4.

Simulated structures reproduce chromosome sizes, positions, and the localization of genome subcompartments. (a) Comparison between chromosome radius of gyrations from simulations and from DNA-MERFISH experiments (28). The Pearson’s correlation coefficient ($r=0.86$) is also shown. (b) Overlap of the probability distributions for the radius of gyration of chromosome 3 computed from the experimental and simulated structural ensemble. (c) Comparison of the chromosome radial positions in experiment (88) and simulations. Here$,R_0$ is the radius of the nucleus, and $R_0=13\sigma =5\mu$m. (d) Distribution of genome subcompartments as a function of distance from nuclear lamina ($d_{\text{lam}}$) and speckles ($d_{\text{spec}}$), respectively, shown for DNA-MERFISH imaging (28) and simulation data. To see this figure in color, go online.