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Major structural changes during SMO activation. (A) Comparison of the broken D-R-E network and the W-R π-cation lock, and the expanded tunnel, in inactive (magenta, 5L7D (32)) vs. active (green, 6XBL (39)) SMO. (B) Comparison of inactive and active SMO, indicating the outward movement of the TM6 and TM3 and inward movement of TM5 in active SMO. To see this figure in color, go online.
