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Allosteric pathways between and . (A) Pathway in Apo-inactive SMO. Since the tunnel radius is decreased, TM6 outward movement is restricted, and therefore the entire allosteric communications occurs via TM6. (B) In SANT1-SMO, due to slight outward movement of TM6, the pathways switches from TM7 to TM6 to TM3. (C and D) SAG-SMO and Apo-active SMO show the same allosteric pathway, which spans TM7-TM6-TM5-TM3. To see this figure in color, go online.
