Table 3.
Sleep Duration Regularity and Associations With Subclinical Markers of CVD: the MESA Sleep Study (2010–2013)
| Sleep duration regularity (nightly within‐person SD) | ||||
|---|---|---|---|---|
| ≤60 min | 61–90 min | 91–120 min | >120 min | |
| Prevalence ratio (95% CI) | ||||
| Coronary artery calcium (>0) | ||||
| n (%) | 363 (65.5) | 273 (65.5) | 211 (66.1) | 180 (69.5) |
| Model 1 | (Reference) | 1.06 (0.97–1.16) | 1.04 (0.95–1.14) | 1.10 (1.00–1.21)* |
| Model 2 | (Reference) | 1.05 (0.97–1.15) | 1.03 (0.94–1.13) | 1.08 (0.98–1.19) |
| Model 3 | (Reference) | 1.06 (0.98–1.16) | 1.03 (0.94–1.13) | 1.07 (0.98–1.18) |
| Coronary artery calcium (>300) | ||||
| n (%) | 113 (20.4) | 84 (20.1) | 78 (24.4) | 67 (25.9) |
| Model 1 | (Reference) | 1.16 (0.91–1.47) | 1.28 (1.01–1.61)* | 1.42 (1.10–1.84)* |
| Model 2 | (Reference) | 1.19 (0.94–1.51) | 1.28 (1.01–1.62)* | 1.40 (1.09–1.81)* |
| Model 3 | (Reference) | 1.26 (0.99–1.59) | 1.32 (1.05–1.67)* | 1.33 (1.03–1.71)* |
| Carotid plaque | ||||
| n (%) | 356 (64.1) | 289 (67.5) | 230 (69.3) | 192 (70.3) |
| Model 1 | (Reference) | 1.10 (1.01–1.20)* | 1.10 (1.00–1.21)* | 1.14 (1.03–1.25)* |
| Model 2 | (Reference) | 1.09 (1.00–1.20)* | 1.09 (0.99–1.19) | 1.12 (1.01–1.23)* |
| Model 3 | (Reference) | 1.10 (1.01–1.20)* | 1.09 (0.99–1.20) | 1.09 (0.99–1.21) |
| Carotid IMT (>0.9) | ||||
| n (%) | 183 (34.1) | 133 (32.2) | 119 (36.6) | 98 (37.5) |
| Model 1 | (Reference) | 1.04 (0.87–1.23) | 1.03 (0.86–1.22) | 1.09 (0.91–1.31) |
| Model 2 | (Reference) | 1.00 (0.84–1.19) | 0.99 (0.82–1.18) | 1.07 (0.89–1.29) |
| Model 3 | (Reference) | 0.99 (0.83–1.18) | 0.99 (0.83–1.18) | 1.03 (0.85–1.25) |
| Ankle‐brachial index (<0.9) | ||||
| n (%) | 24 (3.5) | 26 (4.8) | 28 (6.8) | 25 (7.3) |
| Model 1 | (Reference) | 1.37 (0.80–2.35) | 1.64 (0.97–2.75) | 1.85 (1.09–3.15)* |
| Model 2 | (Reference) | 1.43 (0.83–2.44) | 1.62 (0.96–2.73) | 1.91 (1.12–3.26)* |
| Model 3 | (Reference) | 1.50 (0.86–2.59) | 1.62 (0.98–2.70) | 1.75 (1.03–2.95)* |
Coronary artery calcium, n=1549; carotid plaque, n=1588; carotid IMT n=1535; ankle‐brachial index, n=1989. Model 1: age, sex, race and ethnicity, site; model 2: M1+ education, income, work schedule, smoking status, alcohol consumption, physical activity, and body mass index; model 3: M2+systolic blood pressure, diastolic blood pressure, antihypertension medication use, statin medication use, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, prevalent diabetes. CVD indicates cardiovascular disease; IMT, intima‐media thickness; and MESA, Multi‐Ethnic Study of Atherosclerosis.
*
P value <0.05.