Table 3.

Univariable and Multivariable Cox Regression Models for New‐Onset AF After Propensity Score‐Matched Analysis

Variable	Univariate model		Multivariable model 1		Multivariable model 2		Multivariable model 3
	Crude HR (95% CI)	P value	Adjusted HR (95% CI)	P value	Adjusted HR (95% CI)	P value	Adjusted HR (95% CI)	P value
PVC count ≥1000	1.49 (1.15–1.91)	0.002	1.50 (1.17–1.94)	0.002	1.52 (1.18–1.97)	0.001	1.42 (1.09–1.84)	0.009
Age ≥60	3.26 (2.41–4.40)	<0.001	3.39 (2.47–4.64)	<0.001	3.49 (2.54–4.79)	<0.001	3.71 (2.70–5.11)	<0.001
Male	1.15 (0.91–1.46)	0.232	1.07 (0.85–1.36)	0.563	1.07 (0.85–1.36)	0.564	1.03 (0.81–1.32)	0.787
Diabetes	1.48 (1.16–1.90)	0.002	1.18 (0.91–1.52)	0.218	1.15 (0.89–1.49)	0.296	1.17 (0.90–1.51)	0.241
Hypertension	1.81 (1.41–2.33)	<0.001	1.05 (0.80–1.38)	0.712	1.07 (0.82–1.42)	0.609	1.07 (0.82–1.41)	0.612
Heart failure	2.45 (1.88–3.18)	<0.001	2.76 (2.11–3.59)	<0.001	2.76 (2.12–3.61)	<0.001	2.42 (1.83–3.20)	<0.001
Coronary artery disease	1.37 (1.02–1.84)	0.035	1.16 (0.85–1.57)	0.354	1.16 (0.86–1.58)	0.331	1.17 (0.86–1.59)	0.318
Alcoholism	4.05 (1.51–10.89)	0.006			6.97 (2.56–18.94)	<0.001	7.30 (2.68–19.85)	<0.001
Hyperthyroidism	1.54 (0.82–2.90)	0.183			1.70 (0.88–3.28)	0.112	1.52 (0.78–2.96)	0.218
Use of antiarrhythmia drugs	2.26 (1.61–3.18)	<0.001					2.02 (1.41–2.91)	<0.001

AF indicates atrial fibrillation; HR, hazard ratio; and PVC, premature ventricular complex.