TABLE 2.

Distribution of vascular disease outcomes in the randomized trials of calcium alone or calcium plus vitamin D vs. placebo or no treatment

No. of participants			No. of disease outcomes
Author, y (citation)	Total No. of participants	No. of treated/control	Any MI1	CHD Death	Any CHD	Any stroke	All-cause mortality
Comparisons of calcium supplements
Baron et al., 1999 [21]	930	464/466	35	16	46	20	47
Grant et al., 2005 [22]	2643	1311/1332	84	99	NA2	104	455
Prince et al., 2006 [23]	1460	730/730	40	22	122	78	92
Reid et al., 2006 [24]	1471	732/739	52	NA	NA	59	63
Bonnick et al., 2007 [25]	563	282/281	0	NA	NA	3	3
Lappe et al., 2007 [26]	733	445/288	4	NA	NA	9	NA
Baron et al., 2015 (17)	834	419/415	4	5	9	2	13
ALL	8634	4383/4251	219	142	177	275	673
Comparisons of calcium plus vitamin D supplements
Chapuy et al., 1992 [5]	3270	1634/1636	NA	NA	NA	NA	532
Chapuy et al., 2002 [27]	583	389/194	NA	NA	NA	NA	116
Grant et al., 2005 [22]	2638	1306/1332	83	83	NA	108	437
Jackson et al., 2006 [4]	36,282	18,176/18,106	730	280	1010	726	1584
Salovaara et al., 2010 [28]	3195	1586/1609	35	5	38	46	33
Baron et al., 2015 [27]	836	421/415	6	7	13	5	15
ALL	46,804	23,512/23,292	854	391	1061	885	2717

¹Any MI includes fatal MI and nonfatal MI.

²N/A denotes not assessed.