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Effects of 5-HT2A and 5-HT1A antagonist pretreatment on HTR and hypothermia induced by 4-PrO-DMT. (A) M100907 pretreatment blocked HTR induced by 4-PrO-DMT. (B - C) WAY100635 pretreatment partially blocked hypothermia produced by 4-PrO-DMT (B) and revealed HTR (C). *, #, or & = statistically significant values (p < 0.05) compared to 0/0, antagonist/0, or 0/4-PrO-DMT conditions, respectively. Data represent mean ± SEM for n = 5–6/dose.
