Table 3.

Data collection timepoints

Data	Baseline preoperative	Day 0 DOS	Day 1	Day 2	Day 7	Day 14	Day 21	Day 30	Day 90
Window (days)	−30 to 0	n/a	n/a	n/a	−1 to +2	−1 to +3	−1 to +3	−1 to +7	−1 to +14
Screening and eligibility criteria	x
Informed consent	x
Randomisation		x
Anaesthetic and intraoperative medications administered		x
Quality of Recovery-15 (QOR-15) instrument	x	x	x	x	x
Patient Health Questionnaire (PHQ) 2/8¶	x				x
Modified Brice Interview±follow up questionnaire for patients who report memories			x					x
Risk Analysis Index surgical frailty assessment	x
Ultra-Brief Confusion Assessment Method (UB-CAM)	x	x	x
Change from preoperative baseline in WHO Disability Assessment Scale 2.0 (WHODAS 2.0)	x							x	x
Patient satisfaction questions									x
Safety and adverse events†		x			x			x	x
Exploratory wearable data‡	x				x	x	x	x

Day denotes the days after surgery.

*At the time of informed consent, the following will be performed: QOR-15, UB-CAM, PHQ-2/PHQ-9, WHODAS 2.0.

†Safety and adverse events include intraoperative awareness, intraoperative undesired patient movement, acute kidney injury, respiratory failure, intraoperative hypotension (mean arterial pressure (MAP) <65 mm Hg for 20 min or greater and MAP<55 mm Hg for 20 min or greater), all-cause 30-day mortality, propofol related infusion syndrome, malignant hyperthermia, unplanned admission after outpatient surgery in an ambulatory setting.

‡FitBit or Apple Watch baseline data will be collected 7–14 days prior to surgery, after informed consent.

DOS, day of surgery.