TABLE 2.
In vitro serial passaging of SF100 S. mitis-oralis strain in combination of distinct concentrations of DAP with CRO versus DAP alone
| Distinct concentrations (μg/mL) of DAP alone and DAP + CRO |
DAP MICs (μg/mL) of strain 351 passaged in ascending concentrations of DAP alone or DAP + CRO on distinct days |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| D1 | D2 | D3 | D4 | D5 | D6 | D7 | D8 | D9 | D10 | |
| DAP (5) | 2 | 2 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| DAP (10) | 2 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| DAP (20) | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 | >256 |
| DAP (5) + CRO (0.0156) | 1 | 1 | 1 | 1 | 4 | 4 | 4 | 4 | 4 | 4 |
| DAP (10) + CRO (0.0156) | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 |
| DAP (20) + CRO (0.0156) | 0.5 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |