TABLE 3.

Treatment of 351 S. mitis-oralis strain with ascending dosages of DAP in combination of CRO versus DAP and CRO alone in in vivo IE model^a

Treatment	Vegetation [sterile] (/= Growth on DAP 2 mg/L plates)b	Kidney	Spleen
Untreated controls (7)	8.49 ± 0.65	5.27 ± 0.71	5.26 ± 0.36
DAP 4 mg/kg i.v. once daily × 4 d (7)	7.66 ± 0.87/6.14 ± 1.47c	4.16 ± 0.78c	4.20 ± 0.99c
DAP 6 mg/kg (7)	7.43 ± 1.06d/6.09 ± 0.93d	3.90 ± 0.67d	5.06 ± 1.22
DAP 8 mg/kg (6)	8.24 ± 0.82/6.50 ± 1.53e	4.71 ± 0.91	4.94 ± 0.80
DAP 10 mg/kg (6)	7.50 ± 1.08/5.53 ± 0.51f	4.18 ± 0.49f	4.13 ± 0.52f
DAP 12 mg/kg (7)	7.14 ± 1.04g/6.63 ± 1.04g	3.96 ± 0.59g	3.79 ± 0.53g
DAP 18 mg/kg (6)	8.12 ± 0.79/7.79 ± 0.83	3.94 ± 0.51	4.99 ± 0.30
CRO 40 mg/kg i.v. twice daily × 4 d (7)	7.81 ± 0.65	3.94 ± 0.51h	4.53 ± 1.04
DAP (4 mg/kg) + CRO (6)	5.51 ± 1.18i,j,k /0.62 ± 0.07i,j,k	1.93 ± 0.72i,j,k	2.49 ± 0.48i,j,k
DAP (8 mg/kg) + CRO (6)	0.62 ± 0.07l,m,n /0.62 ± 0.07 [6/6]l,m,n	0.69 ± 0.08 [6/6]l,m,n	0.76 ± 0.13 [6/6]l,m,n

^aStatistical differences for Untreated controls versus DAP 4, 6, 8, 10, 12 mg/kg; Untreated controls versus CRO alone; Untreated controls versus DAP + CRO; combination of DAP + CRO versus DAP alone; combination of DAP + CRO versus CRO alone were determined by Student's t test.

^bThese designations define the number of sterile target tissues/number sampled (e.g., 6/6 = all 6 target tissues were sterilized), as well as the proportion of vegetations having DAP-R subpopulations as defined by growth on DAP plates (2 mg/L).

^cP < 0.05 untreated controls versus DAP 4 mg/kg.

^dP < 0.05 untreated controls versus DAP 6 mg/kg.

^eP < 0.05 untreated controls versus DAP 8 mg/kg.

^fP < 0.01 untreated controls versus DAP 10 mg/kg.

^gP < 0.05 untreated controls versus DAP 12 mg/kg.

^hP < 0.005 untreated controls versus CRO alone.

ⁱP < 0.005 DAP 4 mg/kg + CRO versus DAP 4 mg/kg.

^jP < 0.005 untreated controls versus DAP 4 mg/kg + CRO.

^kP < 0.01 DAP 4 mg/kg + CRO.

^lP < 0.0001 DAP 8 mg/kg + CRO. Parenthesis () = number of rabbits.

^mP < 0.0001 untreated controls versus DAP 8 mg/kg + CRO.

ⁿP < 0.0005 DAP 8 mg/kg + CRO versus DAP 8 mg/kg.