TABLE 2.
Summary of pharmacokinetic parameters for TBP in plasma and total radioactivity in plasma and whole blooda
| Parameter | Estimated plasma TBP | Plasma total radioactivity | Whole blood total radioactivity |
|---|---|---|---|
| AUC0-inf (h·ng/mL)b | Not calculated | 18,500 (28.0) [7] | 8,850 (32.9) [6] |
| AUC%extrap, (%) | Not calculated | 12.1 (22.3) [7] | 13.4 (11.0) [6] |
| AUC0-last (h·ng/mL)b | 8,340 (25.0) [8] | 15,500 (28.6) [8] | 8,570 (35.9) [8] |
| Cmax, (ng/mL)b | 4,540 (46.2) [8] | 5,450 (38.9) [8] | 3,150 (43.2) [8] |
| Tmax (h) | 1.0 (0.5 to 1.5) [8] | 1.0 (0.5 to 1.5) [8] | 1.0 (0.5 to 1.5) [8] |
| Tlast (h) | 12 (12 to 24) [8] | 12 (12 to 24) [8] | 8 (6 to 12) [8] |
| Half-life (h) | Not calculated | 5.98 (55.3) [8] | 3.52 (54.7) [8] |
| AUC0-inf plasma TBP/total radioactivity ratio | Not applicable | Not calculated | Not applicable |
| AUC0-last plasma TBP/total radioactivity ratio | Not applicable | 0.536 (6.3) [8] | Not applicable |
| AUC0-inf, blood/plasma ratio | Not applicable | Not applicable | 0.566 (10.6) [5] |
| AUC0-last, blood/plasma ratio | Not applicable | Not applicable | 0.551 (10.6) [8] |
a
Values are geometric means (CV%) [n]. Tmax and Tlast are medians (min to max) [n]. Not applicable indicates that the value was not determined for the sample. Not calculated indicates that the value was not calculated because the values did not meet the prespecified calculation criteria (due to the adjusted R2 being <0.7 for 7 subjects).
b
The units for the total radioactivity of AUC and Cmax are h·ngEq/g and ngEq/g, respectively.