TABLE 1.

Classification of HIV infections in the CAB arm of HPTN 083^a

Case type	Case description	Infection description	Classification		No. of cases
			Previous report	Current report
A	Baseline infection	HIV positive at study enrollment	A1–A4		4
B	No recent CAB administration	No CAB administration in the 6 mo before the 1st HIV-positive visit	B1–B5	B6–B16	16
C	Oral-phase infection	Infected during the 5-wk oral CAB lead-in phase	C1–C3		3
D	Infected despite on-time injections	Infected <6 mo after the last injection with on-time injections	D1–D4b	D5–D6	6
DX	Delayed injection	Infected <6 mo after the last injection with at least 1 delayed injection (>70 days after the last injection)		DX1–DX3	3
BR	CAB restarted after infection	No CAB administration in the 6 mo before the 1st HIV-positive visit; CAB restarted at or after the 1st HIV-positive visit		BR1–BR2	2
Total no. of cases			16	18	34

^aThe approach used to classify infections in the cabotegravir (CAB) arm of HPTN 083 is shown. Sixteen cases were described in a previous report (3); 18 additional cases are included in this report. HIV testing performed at study sites and the HPTN Laboratory Center was used to determine HIV infection status and identify the first HIV-positive visit. Injections were classified as delayed if they were administered >2 weeks after the planned injection date (>44 days after the 1st injection or >70 days after subsequent injections).

^bOne case that was classified as a D case in the previous report had a single late injection (D1) (75 days after the previous injection); that case would have been classified as a DX case according to the updated classification system used in this report.