FIG 1.

Percent probabilities of PK-PD target attainment by MIC on days 1 and 2 based on the evaluation of the total-drug ELF and free-drug plasma AUC/MIC ratio targets associated with a 1-log₁₀ CFU reduction from baseline for S. pneumoniae (A and B, respectively) among simulated patients after the administration of omadacycline 100 mg i.v. q12h on day 1 followed by 100 mg i.v. q24h on day 2 and 300 mg p.o. q24h on days 3 to 5 overlaid on the MIC distribution for S. pneumoniae.