TABLE 2.

Percentage overlap of either serum 25(OH)D₃ vitamin D₃-regulated or obesity-regulated gene expression in prostate tumors from AA patients with genes annotated by 1α,25(OH)₂D₃-regulated NF regions and/or VDR ChIP-seq

BMI	D3	AA.ChIP.targets	AA.ATAC.targets	NumberTargets	Percent
adj	low	AA.ChIP	AA.ATAC	78	85.7
adj	low	AA.ChIP	indep	13	14.3
adj	low	indep	AA.ATAC	1,217	80.0
adj	low	indep	indep	304	20.0
O	adj	AA.ChIP	AA.ATAC	105	85.4
O	adj	AA.ChIP	indep	18	14.6
O	adj	indep	AA.ATAC	1,852	80.8
O	adj	indep	indep	440	19.2

NOTE: RNA-seq was undertaken in tumors from a cohort of 57 AA and 18 EA patients who underwent radical prostatectomy. Tumor-specific significant DEGs were identified for deficient serum 25(OH)D₃ [serum 25(OH)D₃ levels < 12 ng/mL; low] or obesity (BMI > 30; O). In each case, BMI or 25(OH)D₃ levels were kept as a continuous variable respectively (adj). The DEGs in the AA prostate cancer group (there were no DEGs in the EA prostate cancer group) were overlapped with genes annotated to ATAC-seq or ChIP-seq regions within 100 kb. The percentage overlap of DEGs and cistrome genes is shown.