Table 3.

General multi-omics and AD specific data portals and platforms.

Data portal	Portal description	Citation
OpenNeuro	A free and open platform for validating and sharing Brain Imaging Data Structure (BID)S-compliant MRI, PET, MEG, EEG, and iEEG data	https://openneuro.org/
Enhancing Neuro Imaging Genetics Through Meta-Analysis (ENIGMA)	Consortium to bring together researchers in imaging genomics to understand brain structure, function, and disease, based on brain imaging and genetic data	http://enigma.ini.usc.edu/
Encyclopedia of DNA Elements (ENCODE)	A comprehensive list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active	https://www.encodeproject.org/
Synapse by Sage Bionetworks	A collaborative, open-source research platform that allows teams to share omics, imaging, and phenotypic data, track analyses, and collaborate The AD Knowledge Portal, Brain Somatic Mosaicism Network Portal, Cancer Complexity Knowledge Portal, dHealth Digital Health Knowledge Portal, Neurofibromatosis Portal, and Psychencode Knowledge Portal is powered by Synapse	https://www.synapse.org/
Accelerating Medicines Partnership Program for Alzheimer’s Disease (AMP-AD) Knowledge Portal	Collection of multi-omics data, methods, and results generated within the network are distributed under FAIR Distribution of data principles from: Accelerating Medicines Partnership in Alzheimer’s Disease (AMP-AD), Molecular Mechanisms of the Vascular Etiology of AD (M2OVE-AD) program, Resilience-AD program; (3) the Psych-AD program, Translational Center for Model Development and Evaluation for Late Onset AD (MODEL-AD) program.	https://adknowledgeportal.synapse.org/
AGORA	Hosts evidence for whether or not genes are associated with AD. Agora also contains a list of close to 100 nascent drug targets for AD that were nominated by AD researchers Partnered with NIH-led Accelerating Medicines Partnership – Alzheimer’s Disease (AMP-AD) Target Discovery and Preclinical Validation Project	https://sagebionetworks.org/tools_resources/agora/
Alzheimer’s Disease and Healthy Aging Data Portal	Provides access to national and state level CDC data on a range of key indicators of health and well-being for older adults	https://www.cdc.gov/aging/agingdata/
Single-cell RNA-Seq database for Alzheimer’s disease (scREAD)	A single-cell RNA-Seq database for Alzheimer’s Disease scREAD covers 73 datasets from 16 studies, 10 brain regions, 713,640 cells	https://bmbls.bmi.osumc.edu/scread/
Alzheimer’s Disease Neuroimaging Initiative (ADNI)	ADNI researchers collect, validate and utilize data, including MRI and PET images, genetics, cognitive tests, CSF and blood biomarkers as predictors of the disease. Study resources and data from AD patients, mild cognitive impairment subjects, and elderly controls in the North American ADNI study are available	http://adni.loni.usc.edu/
The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS)	NIAGADS provides qualified investigators with access to a national genetics data repository pertaining to late-onset AD. This site ensures that genotypic data for the study of AD and related dementias (ADRD) are harmonized and shared with the research community at large	https://www.niagads.org/
National Alzheimer’s Coordinating Center (NACC)	Established by the National Institute on Aging/NIH to facilitate collaborative research by collecting data from 29 NLA-funded Alzheimer’s Disease Centers. NACC includes approximately 25,000 subjects, roughly equal parts cognitively normal, MCI and demented. Includes imaging, CSF, and genomic data at autopsy and cross-sectional timepoints	https://www.alz.washington.edu/
Global Alzheimer’s Association Interactive Network (GAAIN)	A big-data community for cohort discovery and data exploration that promotes data sharing among a federated, global network of data partners who are studying AD and other dementias. It is a collaborative project that provides researchers with access to clinical, genetic, and imaging data on Alzheimer’s disease from hundreds of thousands of subject participants	http://www.gaain.org/
The Rush Alzheimer’s Disease Center (RADC) Research Resource Sharing Hub	Site for non-RADC investigators to navigate the complex data and biospecimens available for sharing Provides assistance in identifying data and biospecimens that you can use to support your own projects	https://www.radc.rush.edu/
Alzheimer’s Disease Cooperative Study (ADRCS)	Develop and execute innovative clinical trials focused on interventions that may prevent, delay, or treat the expression of AD and related dementias Committed to sharing resources and tools including data, biospecimens, trial designs, outcome and analysis measures	https://www.adcs.org/