Table 1.
Histopathological diagnosis of B-cell lymphoblastic lymphoma
| Disease | Microcopy | Immunophenotyping |
|---|---|---|
| B-cell lymphoblastic lymphoma | Uniform cells with finely dispersed chromatin and inconspicuous nucleoli | TdT+, CD34+/-, CD43+, CD10+/-, CD79a+, CD19+, CD20-/+, CD99+/-, CD45 +/- |
| Blastoid mantle cell lymphoma | Resemble lymphoblasts, dispersed chromatin and high mitotic count | TdT-, CD5+, CD10-, BCL2+, cyclin D1+, CD4+/- |
| Burkitt lymphoma | Uniform cells with clumped chromatin and several medium-sized nucleoli, ‘starry sky’ pattern | TdT-, CD34-, CD19+, CD20+, CD22+, CD79a+, CD10+, BCL6, BCL2-, surface immunoglobulin+/CD4+/CD56+ |
| Diffuse large B-cell lymphoma | Large cells with vesicular nuclei and prominent nucleoli | TdT-, CD34-, CD1+, CD20+, CD79a+, CD10-/+ |
| Leukaemia cutis (myeloid/myelomonocytic) | Uniform blastic cells | TdT-/+, CD34+, MPO+, myeloid markers+, CD68+and B-cell markers - |
| Ewing sarcoma or primitive neuroectodermal tumour | Small round blue cells | TdT-, CD34-, CD43-, CD79a-, CD99+ |