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. 2023 Apr 18;49(5):530–544. doi: 10.1007/s00134-023-07065-0

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Time course of inflammatory profiles. A, ) PLSDA representations of the 384- inflammatory protein distributions on day 7 in (A) all the patients and (B) in the interferon-gamma group. C Unsupervised heatmap of the filtered proteins on day 7 in patients treated with interferon gamma. D Correlation network of the protein from clusters interferon-1 and interferon-2. E Kaplan–Meier estimates of the ICU hospitalization rate among patients of clusters interferon-1 and interferon-2. F Relative expressions of CCL17 in patients with or without HAP, treated with placebo or interferon gamma-1b. Data are presented as mean with standard error of mean. P-values calculated by linear mixed-effects models are reported in eTable 5. Interaction (T-g): Interaction between the effects of time and of groups (treatment)