Role of Wnt signaling in mouse dermal fibroblast specification and step-wise differentiation to subtypes. Surface ectoderm Wnts are crucial for specification of dermal fibroblast precursors. In the absence of dermal β-catenin or Lef1, dermal fibroblasts progenitors are not specified. Dermal Wnt signaling is also required to generate papillary, reticular and dermal condensate (DC) lineages. Ezh2, an epigenetic regulator, is required to maintain the domain-specific Wnt signaling activation between E11.5 and E13.5. Alpl, alkaline phosphatase; DS, dermal sheath; DP, dermal papilla; DWAT, dermal white adipocytes. Hatched line with a question mark is a possible route of differentiation.